WordNet
n. a state of depression so severe that the person loses contact with reality and suffers a variety of functional impairments [ant: neurotic depression]
Wikipedia
Psychotic depression, also known as depressive psychosis, is a major depressive episode that is accompanied by psychotic symptoms. It can occur in the context of bipolar disorder or major depressive disorder. It can be difficult to distinguish from schizoaffective disorder, a diagnosis that requires the presence of psychotic symptoms for at least two weeks without any mood symptoms present. Conversely, psychotic depression requires that the psychotic features occur only during episodes of major depression. Diagnosis using the DSM-IV involves meeting the criteria for a major depressive episode, along with the criteria for the "psychotic features" specifier.
Usage examples of "psychotic depression".
Until further progress was made in the treatment of paranoid schizophrenia and psychotic depression there wasn't much more we could do for her.
The theory is that a hormone, cortisol, is associated with psychotic depression and RU-486 blocks the brain's receptors for cortisol.
They probably didn't even consider data, they probably were just hungry and hostilesome kind of psychotic depression before they started biting each other!
Now she lived in a psychiatric hospital in the south of England, afflicted with a combination of post-traumatic stress syndrome and psychotic depression.