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PSW may refer to:

  • Pacific South West, a region of the United States of America and Canada
  • Pairwise Smith-Waterman algorithm, a matrix-based genecomparison algorithm
  • Personal Support Worker, a Canadian term for a care worker
  • PlayStation World, a British video game magazine
  • Polish–Soviet War, February 1919–March 1921
  • Program status word, a control register in IBM System/360 and successors systems architecture
  • Baillie-PSW primality test, a mathematical deterministic primality testing heuristic
  • Psychiatric Social Worker, a social worker who works with mentally ill people
  • Part Submission Warrant, a document summarizing the package of documents used in a Production part approval process

PsW' may refer to: