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PSSM may refer to:

  • Parallel-Split Shadow Map
  • Position-Specific Scoring Matrix
  • Pretty Soldier Sailor Moon, the official English translation of the series, often shortened as Sailor Moon
  • Principles and Standards for School Mathematics, a policy book on mathematics education
  • Polysaccharide storage myopathy, aka Equine polysaccharide storage myopathy (PSSM or EPSM), a disease in horses
  • Positive sleep state misperception, subjective hypersomnia without objective findings.
  • Rhizobium leguminosarum exopolysaccharide glucosyl ketal-pyruvate-transferase, an enzyme