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Poulos is the Greek-origin surname for:

  • Brett Poulos, involved in a 2010 dispute over First Amendment rights
  • Dimmi Poulos, nickname of Dimitra Tsiliaskopoulos, Australian football goalkeeper
  • Ernie T. Poulos (1926-1997), American Thoroughbred horse trainer
  • George R. Poulos, Michigan politician
  • Georgios Poulos, Nazi collaborator during the Axis occupation of Greece
  • Ioannis Poulos, Greek fencer competitor at the 1896 Summer Olympics in Athens
  • Jimmy Poulos (born 1952), American player of gridiron football
  • Leah Poulos-Mueller (born 1951), American former speed skater

It can also refer to:

  • Alex Poulos, a fictional character from the Australian soap opera Home and Away
  • Leah Poulos, birth name of Leah Patterson-Baker, another fictional character of the Australian soap opera Home and Away
  • Poulos v. New Hampshire, a 1953 case of the Supreme Court of the United States