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Poictesme (pronounced "pwa-tem") is a fictional country or province which forms the setting of the fantasy works of James Branch Cabell, known collectively as Biography of the Life of Manuel. Poictesme is ruled by the Count Dom Manuel.

It was the author's intention to situate Poictesme roughly in the south of France. The name suggests the two real French cities of Poitiers (medieval Poictiers) and Angoulême (medieval Angoulesme).

At the height of Cabell's popularity in the 1920s, Cabell's publishers sold framed wall-maps of Poictesme.

The Virginia Commonwealth University undergraduate literary journal is named Poictesme after the fictional province.