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PNI may refer to:

  • Palestinian National Initiative, a Palestinian political party
  • Partai Nasional Indonesia ( Indonesian National Party), a former Indonesian political party
  • Perineural invasion, cancer spreading along a nerve
  • PNI, IATA Airport Code for Pohnpei International Airport in Micronesia
  • PNI Digital Media (Photochannel Networks Inc), a US company that operates an on-demand photographic printing service
  • Prescott New Instructions, also known as SSE3, an instruction set introduced with the Intel Prescott processor in 2004
  • Private Network Interconnect, a method of Internet peering
  • Psychoneuroimmunology, the study of interaction between the nervous system and immune system