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Plouffe is a French surname. People with the surname include:

  • David Plouffe (born 1967), American campaign manager
  • Katherine and Michelle Plouffe (born 1992), Canadian basketball players and twin sisters
  • Simon Plouffe (born 1956), Quebec mathematician
  • Steve Plouffe (born 1975), Canadian retired ice hockey goaltender
  • Trevor Plouffe (born 1986), American baseball player
  • La Famille Plouffe, Quebec TV series of the 1950s (and revived in the 1980s)