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Plesictis is an extinct prehistoric genus of mustelid (originally described as a procyonid) endemic to Europe during the Oligocene and Miocene 33.9—20.0 Ma existing for approximately .

Plesictis was a long animal, resembling a weasel with large eyes, or possibly a cacomistle. Its large eyes and very long tail suggest that it may have been nocturnal and arboreal. Judging from its teeth, it was an omnivore.