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PFL may refer to:

  • Pacific Forum Line, a shipping alliance located in Nauru
  • Paid Family Leave (California), a California law that extends unemployment disability compensation
  • Partido da Frente Liberal ( Liberal Front Party (Brazil), a Brazilian political party
  • Peel Football League, an Australian rules football league
  • PFL, ISO 639-3 language code for the Palatine German language
  • Pioneer Football League, an NCAA Division I-AA football conference
  • Popular Front of Latvia, a former Latvian political party
  • Pre-fader listen, a sound mixer function used for making a Fade (audio engineering)
  • Priests for Life, an American-based Roman Catholic pro-life organization
  • Professional Football League
    • First Professional Football League (Bulgaria))
    • Professional Football League of Ukraine
    • Russian Professional Football League
    • TT Pro League, formerly the Professional Football League of Trinidad and Tobago
  • Professional Futsal League, an American sports league
  • Pyruvate formate lyase, an enzyme important in the regulation of anaerobic glucose metabolism