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PFE may refer to:

  • Pacific Fruit Express, a railroad refrigerator car leasing company
  • Parathyroid hormone 1 receptor protein
  • Partial fraction expansion
  • Pelvic floor exercise, also known as Kegel exercise
  • Permanent Fatal Error (a French post-rock band by Ulan Bator founder member)
  • Pfizer Inc., New York Stock Exchange symbol PFE
  • PolyGram Filmed Entertainment
  • Portable Forth Environment, an Open source implementation of the Forth programming language
  • Potential future exposure, the maximum expected credit exposure over a specified period of time
  • Programmer's File Editor
  • Product Family Engineering