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Perdesonide

Perdesonide is a glucocorticoid steroid. It is closely related to budesonide and differs by having a difluorinated steroid skeleton. The introduction of the 2 fluorines to the steroid skeleton was shown to increase systemic activity to a greater degree than local activity.' Perdesonide resembles clocortolone in that both have two halide atoms; perdesonide has two fluorine atoms and clocortolone has one chlorine atom and one fluorine atom.' Perdesonide is racemic at the carbon of the acetal. The R-isomer of the acetal as in (R)-Perdesonide is more active.