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The initials PDE can stand for:

  • Page Directory Entry, a list of page table addresses in computer science
  • " Parade" on street signs
  • Partial differential equation, a differential equation involving partial derivatives of a function of several variables
  • European Democratic Party (EDP), in Spanish, French and Italian
  • Phosphodiesterase, a kind of enzyme important in intracellular communication
  • Photon detection efficiency
  • Eclipse (software), plug-in development environment
  • Polydichloric euthimal (sometimes spelled "Polydichloric euthimol"), a fictitious man-made chemical seen in the films Outland, Terminator 2: Judgment Day, and The Relic
  • Portable Development Environment, File extension for processing source code
  • Position Determining Entity, used by cellular phone companies for location determination
  • Position Determining Equipment, used by cellular phone companies for location determination
  • Power Drive Electronics
  • Prescription Drug Event (PDE)
  • Present Day English
  • Principle of double effect
  • Printing Dialog Extensions a user interface for changing printer options in Mac OS X.
  • Program Development Environment, an Integrated Development Environment editing and debugging tool used during software development
  • Projectile Development Establishment UK research establishment based at Fort Halstead, and later Aberporth
  • Pug dog encephalitis
  • Pulse Detonation Engine a proposed substitute to the traditional jet engine.