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Poly (ADP-ribose) glycohydrolase is an enzyme that in humans is encoded by the PARG gene.

Poly (ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly ( ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.