Pacôme is a French masculine given name, and sometimes surname, taken from the French spelling of Pachomius, primarily in reference to Saint-Pacôme, Pachomius the Great.
- Éric Pacôme N'Dri (1978) Ivorian 100 metres runner
- Pacôme Thiellement, French essayist
- Pacôme Assi, French kickboxer
- Charles Pacôme (1902-1978) French wrestler