The surname Osti may refer to:
- Massimo Osti (1944–2005), Italian garment engineer
- Carlo Osti (born 1958), Italian professional football player
- Josip Osti (born 1945), Bosnian poet, prose writer and essayist, literary critic, anthologist and translator.
Osti or OSTI may refer to:
- Office of Scientific and Technical Information
- Osti (surname)
- Ordre Souverain du Temple Initiatique