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Osini is a comune (municipality) in the Province of Nuoro in the Italian region Sardinia, located about northeast of Cagliari and about southwest of Tortolì. As of 31 December 2004, it had a population of 925 and an area of .

In its territory is located the Nuraghe Serbissi.

Osini borders the following municipalities: Cardedu, Gairo, Jerzu, Lanusei, Loceri, Tertenia, Ulassai, Ussassai.