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OSD may refer to:

  • Åre Östersund Airport, in Sweden, IATA airport code
  • Object storage device, computer data storage device that manages data as objects
  • Ocean Science Discussions, the discussion and review section of the journal Ocean Science
  • Office of the Secretary of Defense, the principal staff of the United States Secretary of Defense
  • Officer on Special Duty (India), an Indian civil service post
  • Oklahoma School for the Deaf, a K-12 residential school for the deaf or hard-hearing students
  • On-screen display, a feature of visual devices like VCRs and DVD players that displays program, position, and setting data on a connected TV or computer display
  • One Shot Deal, a live album by Frank Zappa posthumously released in 2008
  • Open Source Definition, criteria used by the Open Source Initiative to determine whether or not a software license can be considered open source
  • OpenSearch Description document, an XML file format that identifies and describes a search engine
  • Operating System Deployment, a component of Microsoft's System Center Configuration Manager product
  • Optimal shape design, a part of the field of optimal control theory
  • Osgood–Schlatter disease, an inflammation of the growth plate at the tibial tuberosity which occurs mostly in teenage boys
  • Overseas Surveys Directorate, the United Kingdom's central survey and mapping organisation for British colonies and protectorates 1984–1991