Osca or OSCA may refer to:
- O.S.C.A., a brand of Italian sports cars
- Oberlin Student Cooperative Association, a non-profit student cooperative at Oberlin College
- Huesca or Osca, a city in Spain
- Huéscar, Granada or Osca, a municipality in Spain
- " OSCA" a song by Japanese band Tokyo Jihen, from the album Variety (2007)
- O.S.C.A. inc. the Ocean Shores Community Association in Byron Shire, NSW, Australia.
- OSCA Pty.Ltd. trading as OSCA, Specialising in Ironing and providing business services and training to small business and the ironing service industry. Melbourne, Australia.
"OSCA" is a song by Japanese rock band Tokyo Jihen, led by musician Ringo Sheena. It was released as the band's fourth single on July 11, 2007, as one of the two singles before the band's third album Variety (2007). It was the first and only single released by the band that did not feature writing by vocalist Sheena, instead created by the band's second guitarist, Ukigumo.