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OPX may refer to:

  • OPX (meteorite class), a class of Martian meteorites
  • Off-premises extension, an extension telephone at a location distant from its servicing private branch exchange
  • Open Programming Extension, the DLL mechanism of the Open programming language of the Symbian operating system for mobile phones
  • Orthopyroxene, a pyroxene, a type of rock-forming mineral
  • Silver Xpress, a mail format used on FidoNet