Wikipedia
OpenMDAO is an open-source Multidisciplinary Design, Analysis, and Optimization (MDAO) framework, written in the Python programming language.
The OpenMDAO framework is designed to aid in linking together separate pieces of software for the purpose of combined analyses. It allows users to combine analysis tools (or design codes) from multiple disciplines, at multiple levels of fidelity, and to manage the interaction between them. OpenMDAO is specifically designed to manage the dataflow (the actual data) and the workflow (what code is run when) in conjunction with optimization algorithms and other advanced solution techniques.
The development of OpenMDAO is led out of the NASA Glenn Research Center, with support from the NASA Langley Research Center.