OKC may refer to:
Oklahoma City, the capital and largest city of the U.S. state of Oklahoma
- Oklahoma City Thunder, the city's National Basketball Association (NBA) team
- Will Rogers World Airport, the city's commercial airport (IATA abbreviation: OKC; ICAO abbreviation: KOKC)
- OkCupid, American online dating website
- Ontario Knife Company, Franklinville, New York
- Odontogenic keratocyst, a tumor in the jaw now referred to as "keratocystic odontogenic tumor"