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OKC may refer to:

  • Oklahoma City, the capital and largest city of the U.S. state of Oklahoma
    • Oklahoma City Thunder, the city's National Basketball Association (NBA) team
    • Will Rogers World Airport, the city's commercial airport (IATA abbreviation: OKC; ICAO abbreviation: KOKC)
  • OkCupid, American online dating website
  • Ontario Knife Company, Franklinville, New York
  • Odontogenic keratocyst, a tumor in the jaw now referred to as "keratocystic odontogenic tumor"