OFS may stand for:
- Ottawa Fire Service
- Oklahoma Office of State Finance
- A division of Operations Feedback ("Operations Feedback Systems"), developers of OEE, productivity and efficiency solutions.
- Amiga Old File System
- Object File System, supposed to be included as part of Cairo operating system
- Office of Financial Stability
- Schlumberger Oilfield Services, a division of Schlumberger Limited
- Operation Freedom's Sentinel, a U.S. led counterterrorism mission in Afghanistan since Jan 1, 2015.
- Orange Free State, a province of South Africa
- Overseas Family School, a school in Singapore
- One Fell Swoop, a band in Toronto, Canada
- Orley Farm School, a North-London prep school
- OFS, formerly "Optical Fiber Solutions", a division of Furukawa Electric (but formerly part of Lucent)
- Secular Franciscan Order (; abbreviated OFS)
- OFS (Only Finest Selection), in a wine context, usually in reference to only premium grapes being used for a particular wine production.
- OFS Studio ( Old Fire Station), Oxford, England
- Offer for Sale