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The Collaborative International Dictionary
Of course

Course \Course\ (k[=o]rs), n. [F. cours, course, L. cursus, fr. currere to run. See Current.]

  1. The act of moving from one point to another; progress; passage.

    And when we had finished our course from Tyre, we came to Ptolemais.
    --Acts xxi. 7.

  2. The ground or path traversed; track; way.

    The same horse also run the round course at Newmarket.
    --Pennant.

  3. Motion, considered as to its general or resultant direction or to its goal; line progress or advance.

    A light by which the Argive squadron steers Their silent course to Ilium's well known shore.
    --Dennham.

    Westward the course of empire takes its way.
    --Berkeley.

  4. Progress from point to point without change of direction; any part of a progress from one place to another, which is in a straight line, or on one direction; as, a ship in a long voyage makes many courses; a course measured by a surveyor between two stations; also, a progress without interruption or rest; a heat; as, one course of a race.

  5. Motion considered with reference to manner; or derly progress; procedure in a certain line of thought or action; as, the course of an argument.

    The course of true love never did run smooth.
    --Shak.

  6. Customary or established sequence of events; recurrence of events according to natural laws.

    By course of nature and of law.
    --Davies.

    Day and night, Seedtime and harvest, heat and hoary frost, Shall hold their course.
    --Milton.

  7. Method of procedure; manner or way of conducting; conduct; behavior.

    My lord of York commends the plot and the general course of the action.
    --Shak.

    By perseverance in the course prescribed.
    --Wodsworth.

    You hold your course without remorse.
    --Tennyson.

  8. A series of motions or acts arranged in order; a succession of acts or practices connectedly followed; as, a course of medicine; a course of lectures on chemistry.

  9. The succession of one to another in office or duty; order; turn.

    He appointed . . . the courses of the priests
    --2 Chron. viii. 14.

  10. That part of a meal served at one time, with its accompaniments.

    He [Goldsmith] wore fine clothes, gave dinners of several courses, paid court to venal beauties.
    --Macaulay.

  11. (Arch.) A continuous level range of brick or stones of the same height throughout the face or faces of a building.
    --Gwilt.

  12. (Naut.) The lowest sail on any mast of a square-rigged vessel; as, the fore course, main course, etc.

  13. pl. (Physiol.) The menses.

    In course, in regular succession.

    Of course, by consequence; as a matter of course; in regular or natural order.

    In the course of, at same time or times during. ``In the course of human events.''
    --T. Jefferson.

    Syn: Way; road; route; passage; race; series; succession; manner; method; mode; career; progress.

Wiktionary
of course

adv. 1 (&lit of course English) 2 (lb en idiomatic) (non-gloss definition: Indicates enthusiastic agreement.) 3 (lb en idiomatic) (non-gloss definition: Acknowledges the validity of the associated phrase.) 4 (lb en idiomatic) (non-gloss definition: Asserts that the associated phrase should not be argued, particularly if it is obvious or there is no choice in the matter.)

WordNet
of course

adv. as might be expected; "naturally, the lawyer sent us a huge bill" [syn: naturally, course] [ant: unnaturally]

Wikipedia
Of Course (How I Met Your Mother)

"Of Course" is the 17th episode of the fifth season of the CBS sitcom How I Met Your Mother and 105th episode overall. It originally aired on March 8, 2010.

Usage examples of "of course".

Your name just slipped my mind a moment--and then, of course, it all flashed over me.

At just this moment the train had entered the State of Virginia, although, of course, none of the men who sat there talking knew this.

EVERYONE, of course, KNEW that King Lear was one of the greatest plays that had ever been written.

There is a splendid establishment in the basement of this building--small, of course, but everything clean and of the highest order!

It is, of course, a trifle and perhaps without great significance in the development of the modern theatre, but it is De Musset in rather good form and De Musset in good form is charming.

She was convinced, of course, that her husband was mad and all his opinions nonsensical.

Rimsky, but was too late, of course, either to have heard or to care much for the modern composers.

One man wrote a book called Studies in Ten Literatures--which, of course, is foolish.

Yes, yes, of course it was a thousand times better for the environment, ten thousand times, but still he liked the feel of the gas pedal, preferred it over the accelerator.

In operation, of course, the tunnel is continuous through the experiment.

And, of course, Giorgio immediately recognized the macroscopic ramifications.

Mating with themwell, of course you mated with them: one was always on the lookout for extra women who could add to the knowledge and technical abilities of Mankind.

Except, of course, for this inexcusably sloppy business of escapees like your-self and Roy here.

As a matter of course, in the last few minutes, they had each been turning periodically in one direction and another to see if there were any sign of the Monsters in the surrounding whiteness.

In our terms, of course, and who are we to say that our terms are right?