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ODC may refer to:

  • ODC/Dance, a San Francisco-based dance company
  • Ordinary Decent Criminal (slang), used by the Garda Síochána, the police force of the Republic of Ireland, to distinguish between criminals engaging in illegal practices for financial or personal ends and those who have terrorist goals
  • Ornithine decarboxylase, an enzyme
  • Orthogonal Defect Classification
  • .odc, a file suffix which can identify (inter alia) Microsoft Office "Office Data Connection" files