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The Collaborative International Dictionary

nucleotide \nucleotide\ n. a phosphate ester of a nucleoside; one of the monomeric components of DNA or RNA.

Douglas Harper's Etymology Dictionary

1908, from German nucleotid (1908), from nucleo-, modern comb. form of Latin nucleus (see nucleus) + -ide, with -t- for the sake of euphony.


n. (context biochemistry English) the monomer comprising DNA or RNA biopolymer molecules. Each nucleotide consists of a nitrogenous heterocyclic base (or nucleobase), which can be either a double-ringed purine or a single-ringed pyrimidine; a five-carbon pentose sugar (deoxyribose in DNA or ribose in RNA); and a phosphate group.


n. a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA)


Nucleotides are organic molecules that serve as the monomers, or subunits, of nucleic acids like DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). The building blocks of nucleic acids, nucleotides are composed of a nitrogenous base, a five-carbon sugar ( ribose or deoxyribose), and at least one phosphate group. Thus a nucleoside plus a phosphate group yields a nucleotide.

Nucleotides also function to carry packets of energy within the cell in the form of the nucleoside triphosphates ( ATP, GTP, CTP and UTP), playing a central role in metabolism. In addition, nucleotides participate in cell signaling ( cGMP and cAMP), and are incorporated into important cofactors of enzymatic reactions (e.g. coenzyme A, FAD, FMN, NAD, and NADP).

In experimental biochemistry, nucleotides can be radiolabeled with radionuclides to yield radionucleotides.

Usage examples of "nucleotide".

They represented the nucleotides adenine, thymine, guanine, and cytosine.

She had used the base pairs of the DNA---combinations of pairs of four nucleotides called adenine, guanine, cytosine, and thy mine--to encode her message.

For the rule linking nucleotide sequences to protein synthesis to be determined experimentally, Cyfer must first play with its shape, its inner symmetries.

Ressler goes on, explaining how Cyfer has squared off against the coding problem, just what difficulties still lie between them and a map of the nucleotide grammar.

Just because one nucleotide varies, does not determine how cytochrome c evolved in other species, long before man or monkey.

But what about your phylogenetic tree for cytochrome c and the vast nucleotide changes between the earlier species?

DNA molecules, deoxyribose sugar, the phosphate unit and especially the nucleotides.

He worked exclusively with the so-called junk DNA in rats, introducing a selective catalyst through the cell wall on a folic acid carrier to delete specific but unimportant nucleotides.

After several sixteen-hour days, Daniel succeeded in attaching the appropriate fragments with nucleotide ligases to form the genes.

A, G, C, and T usually stood for the nucleotides, plus two more named PU-3 and PY-3, indicating an addition purine and pyrimidine.

Meanwhile, TTT, which made phenylalanine, coded for a nucleotide insertion, while its synonym TTC was the instruction for a nucleotide deletion.

We lacked enough material to test for trace constituents, but later on with more eggs at our disposal we did and nothing unusual showed up as far as contents of vitamins, coenzymes, nucleotides, sulfhydryl groups, et cetera, et cetera were concerned.

A simple lookup table, one or more triplets of nucleotides to each amino acid, is universal for all life.

Its telomere should have been completely rebuilt, which meant that the nucleotide sequence ought to repeat about fifteen hundred times.

The telomere was far too short, no more than a few hundred repetitions of the same pattern of the six nucleotide bases.