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NRON also known as ncRNA repressor of the nuclear factor of activated T cells is a non-coding RNA involved in repressing NFAT. The function of this ncRNA was identified by a large-scale screen of 512 non-coding RNAs discovered in earlier EST sequencing projects.

Each of the RNAs that were conserved between human and mouse were knocked down using shRNAs. The resulting cell-lines were screened for changes in activity of NFAT.