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NMO may refer to:

  • Neuromyelitis optica, also known as Devic's disease or Devic's syndrome
  • N-Methylmorpholine N-oxide, an organic compound
  • Nitronate monooxygenase, an enzyme
  • Normal Move Out, in reflection seismology
  • The National Measurement Office, a government agency in the United Kingdom
  • New Motorola, a mobile antenna connector