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NKC is a three letter abbreviation that may refer to:

  • IATA airport code for Nouakchott–Oumtounsy International Airport
  • National Kennel Club, all-breed dog registry in the United States
  • Nat King Cole, American jazz singer/musician
  • Northwest Kidney Centers, outpatient hemodialysis treatment center
  • Natural killer cell, cell involved in the innate immune system
  • National Knowledge Commission, Indian Commission set up by Manmohan Singh