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Nishi-Shinjuku

is a skyscraper business district in Shinjuku, Tokyo, Japan. This region was previously called .

Nishi-Shinjuku was Tokyo's first major foray into building skyscrapers with the first appearing in the 1970s with Keio Plaza Inter-Continental. It is the location of the Tokyo Metropolitan Government Building, the headquarters of the Tokyo Metropolitan Government.

Progress continues in Nishi-Shinjuku, which is heading away from the city centre and has the site of the proposed Nishi-Shinjuku 3-Chōme Redevelopment, with plans for what will be three of the four tallest buildings in Japan.