NASCO or Nasco may refer to:
- Nasco (grape), an Italian grape variety
- Nasco Agricultural Sciences, a Wisconsin company
- Nasco Group, a set of companies founded by Ahmed Idris Nasreddin
- National Accounts Services Company
- National Steel and Shipbuilding Company, a shipyard in San Diego, CA owned by General Dynamics
- Native American Services Corp.
- Noi Bai Airport Services Joint Stock Company, in Vietnamese Công ty Cổ phần Dịch vụ Hàng không Sân bay Nội Bài
- North American Students of Cooperation
- North American SuperCorridor Coalition
- North Atlantic Salmon Conservation Organization
- ORS Nasco, an Oklahoma company trading in industrial products
- National Association of State Charity Officials
Nasco is a white Italian wine grape variety that is grown primarily in Sardinia around the city of Cagliari. The grape has a long history on the island and is described by wine expert Jancis Robinson as "ancient". There is a special Denominazione di origine controllata (DOC) designation, Nasco di Cagliari, for varietal wines that are 95–100% Nasco.