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MVB may refer to:

  • Martin Van Buren (1782-1862), eighth President of the United States
  • Mark van Bommel (b. 1977), Dutch soccer player
  • Marco van Basten (b. 1964), Dutch soccer legend
  • Multivesicular body, a specialized endosome which itself contains internal vesicles
  • Multifunction Vehicle Bus, a data line used in train control systems
  • Bachelor of Veterinary Medicine (MVB) degree awarded by University College Dublin