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MPN may refer to:

  • Manufacturer part number, an identifier
  • Master promissory note, a wide-encompassing accounting contract
  • Metal-phenolic network, a supramolecular coordination structure consisting of metal ions and polyphenols
  • Microsoft Partner Ecosystem (also known as Microsoft Partner Network), a network of Microsoft partners and vendors
  • Mobil Producing Nigeria, a Nigerian petroleum company
  • Most probable number, a method for estimating counts from positive/negative data
  • Movimiento Popular Neuquino, a provincial political party in the province of Neuquén, Argentina
  • Myeloproliferative neoplasms, a family of blood cancers in which excess cells are produced
  • RAF Mount Pleasant (IATA airport code), a British military base in the Falkland Islands