Mkuze is a small town in Northern KwaZulu-Natal, South Africa. It is located approximately 350 km from the city of Durban. It is along the N2 road en route to Johannesburg, Swaziland and Mozambique; between the Mkuze River and Intaba Yemikhovu (Ghost Mountain). Mkuze is some distance from other small towns such as Hluhluwe (50 km), Nongoma (76 km), Pongola (65 km), and Jozini (25 km it is said that Intaba Yemikhovu is where the King Dingaan was killed by the King Shaka's son Mhlophekazi who was known as Mbophe's son. Even though it is believed he died near Tugela river
Mkuze is the seat of Umkhanyakude District Municipality.