What is "mitraphylline"

n. (context organic compound English) An oxindole derivative found in the leaf of the tree ''Mitragyna speciosa''.

Mitraphylline, an oxindole derivative, is an active alkaloid in the leaves of the tree Mitragyna speciosa, commonly known as kratom. As a non-narcotic constituent, it also occurs to a significant amount in the bark of Uncaria tomentosa (Cat’s Claw) along with a number of isomeric alkaloids. Due to its structural similarity to mitragynine and 7-hydroxymitragynine from kratom, effects on mu and delta opiate receptors as well as NMDA-antagonistic actions have been postulated.

Current research is focusing on antiproliferative and cytotoxic effects and its in vivo efficacy to induce apoptosis in human breast cancer, sarcoma as well as lymphoblastic leukaemia cell lines.