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Mialoquo (Cherokee town)

Mialoquo (also "Malaquo", "Big Island", or "Great Island") is a prehistoric and historic Native American site in Monroe County, Tennessee, in the southeastern United States. The site saw significant periods of occupation during the Mississippian period (c. 1000-1600 AD) and later as a Cherokee refugee village. While the archaeological site of Mialoquo was situated on the southwest bank of the Little Tennessee River, the village's habitation area probably included part of Rose Island, a large island in the river immediately opposite the site. Rose Island was occupied on at least a semi-permanent basis as early as the Middle Archaic period.

Both the Mialoquo site and Rose Island are now submerged by the Tellico Lake impoundment of the Little Tennessee River. The area is now managed by the Tennessee Valley Authority and the Tennessee Wildlife Resources Agency. Both sites are visible looking north from the U.S. Route 411 bridge over the river in Vonore or looking west from Wildcat Point, a cliff on the eastern bank of the river.