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MHS may refer to:

  • Air Memphis, and Egyptian airline that uses the ICAO code MHS
  • Malignant hyperthermia syndrome, a condition that is triggered by exposure to drugs used for general anaesthesia
  • Master of Health Science, a graduate degree program
  • Meadowhall Interchange, a railway station in England that uses the National Rail station code MHS
  • Message Handling System, a past Novell email protocol
  • Michigan Humane Society, an organization providing animal welfare and sheltering services
  • Microwave Humidity Sounder, an Earth-observing instrument on NOAA POES and EUMETSAT MetOp satellites
  • Military Health System, the United States Department of Defense health care system
  • Modular Handgun System
  • Montana Historical Society
  • Monument historique, Monuments Historiques et Sites, is a French external reference, in France
  • Mormon Historical Studies, a semiannual Mormon History journal
  • Mull Historical Society, a name under which Scottish indie musician Colin MacIntyre has recorded
  • Museum of the History of Science, a museum in Oxford, England
  • RAF Menwith Hill, also known as Menwith Hill Station (MHS), a Royal Air Force station in Yorkshire, UK