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methylmalonic acid

n. (context organic compound English) A dicarboxylic acid that is a C-methylated derivative of malonate.

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Methylmalonic acid

Methylmalonic acid (MMA) ( conjugate base methylmalonate) is a dicarboxylic acid that is a C- methylated derivative of malonate.

The coenzyme A linked form of methylmalonic acid, methylmalonyl-CoA, is converted into succinyl-CoA by methylmalonyl-CoA mutase, in a reaction that requires vitamin B as a cofactor. In this way, it enters the Krebs cycle, and is thus part of one of the anaplerotic reactions.