Crossword clues for methotrexate
n. (context medicine English) An antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases.
Methotrexate (MTX), formerly known as amethopterin, is an antimetabolite and antifolate drug.
Methotrexate began to replace the more toxic antifolate aminopterin starting in the 1950s. The drug was originally synthesised by the Indian biochemist Yellapragada Subbarow and clinically developed by the American pediatric pathologist Sidney Farber. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.