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MCO may refer to:

  • Managed Care Organization
  • Manitoba Chamber Orchestra
  • Manufacturer’s Certificate of Origin
  • Marine Corps Order
  • Mars Climate Orbiter
  • Millennial Choirs and Orchestras
  • Miscellaneous Charges Order, a coupon used to process the payment of travel arrangements
  • Modern Chess Openings an important book of chess openings
  • Motorsport Club of Ottawa
  • Motor City Online, a Massively Multiplayer Online Racing Game
  • Maximum Cumulative Outflow
  • MCO, the IATA airport code for Orlando International Airport
  • MCO, the ISO 3166 trigram for the country of Monaco
  • MCO, the ISO 639-3 code for Coatlán Mixe
  • MCO, the NYSE code for Moody's Corporation
  • MCO, the UK National Rail station code for Manchester Oxford Road railway station