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McGuirk may refer to:

  • Ambrose McGuirk, the first owner of the Milwaukee Badgers of the National Football League
  • Bernard McGuirk, the executive producer of the Imus in the Morning radio program
  • Leroy McGuirk (1910–1988), American wrestler and professional wrestling promoter
  • Mike McGuirk (born 1958), American professional wrestling personality
  • Patrick McGuirk (born 1967), American football player
  • Terry McGuirk, chairman of Major League Baseball's Atlanta Braves
  • Warren P. McGuirk (born 1906), Director of Athletics at the University of Massachusetts Amherst