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McDuff (also spelled: Macduff) is a surname. It is the Anglicized form of the Scottish Gaelic name Mac Dhuibh (Mac = son, Dhuibh = dark/black). Notable people with the surname include:

  • Caleb McDuff, Welsh deaf racing driver
  • David McDuff, Scottish literary translator
  • Dusa McDuff, English mathematician
  • Daniel McDuff, Affective Computing Researcher
  • Jack McDuff (1926-2001), American jazz musician
  • Kenneth McDuff (1946-1998), American serial killer

Fictional characters:

  • McDuff, the Talking Dog, a children's television character
  • Suds McDuff, another name for The Simpsons' dog Santa's Little Helper
  • Father Cyril McDuff, a priest in the television series Father Ted