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Mazen may refer to:

  • Mazen Abdul-Jawad (born 1977), Saudi Arabian man who spoke about his sexual exploits on television in July 2009
  • Mazen Al-Najjar, brother-in-law of Sami Al-Arian, jailed for nearly five years, accused of having links to Palestinian terrorists
  • Mazen Asfour, Jordanian art critic who graduated from the University of Bologna, Italy
  • Ahlam Mazen At-Tamimi, Palestinian woman known for assistance in carrying out the Sbarro restaurant suicide bombing
  • Mazen Dana (1962–2003), Palestinian journalist who worked as a Reuters cameraman
  • Mazen Darwish, Syrian lawyer and free speech advocate
  • Mazen Hesham, (born 1994), professional squash player who represents Egypt
  • Abu Mazen (born 1935), President of the State of Palestine and Palestinian National Authority
  • Mazen al-Tumeizi (1978–2004), Palestinian journalist, killed on-camera in Baghdad, Iraq by U.S. helicopter gunfire
  • Mazen Metwaly (born 1990), Saudi Arabian-born Egyptian professional swimmer, specialising in Open water swimming
  • Mazen Mneimneh (born 1986), Lebanese basketball player
  • Mazen Sinokrot, a Palestinian businessman and the founding member of the Sinokrot Global Group