Mayweather is a common surname, and may refer to:
- Anthony Mayweather (born 1985), professional wrestler
- Floyd Mayweather, Jr. (born 1977), Olympic and professional boxer
- Floyd Mayweather, Sr. (born 1952), former boxer and current trainer
- Jeff Mayweather (born 1964), former boxer and current boxing writer/trainer
- Roger Mayweather (born 1961), former boxer and current boxing trainer of Floyd Mayweather, Jr.