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Mayaguana is the most easterly island and district of the Bahamas. It is one of only a few Bahamian islands which retain their Lucayan names. The population of Mayaguana in the 2010 census was 277. It has an area of about 280 km.

About 100 km north of Great Inagua and 560 km southeast of the capital Nassau, Mayaguana is considered the halfway point between South Florida and Puerto Rico and is about 450 nautical miles off Palm Beach, Florida. It is a popular stopover for boaters on a direct route to the eastern Caribbean. It also was one of the first islands that Christopher Columbus landed on during his journey to the new world.