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Masiello is a surname originating in Italy. Notable people with the surname include:

  • Andrea Masiello (born 1986), Italian soccer player
  • Anthony Masiello, Buffalo, New York, politician
  • Desyn Masiello, British producer of electronic music
  • Luciano Masiello (born 1952), Italian-born English and Irish soccer player
  • Salvatore Masiello (born 1982), Italian soccer player
  • Wendy M. Masiello, United States Air Force officer