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Mascoma may refer to:

Locations in the United States
  • The Mascoma River in New Hampshire
  • Mascoma Lake in New Hampshire
Derived from the river or lake
  • Mascoma Corporation, a biofuel company
  • Mascoma Valley Regional High School, Canaan, New Hampshire, United States
  • USS Mascoma (AO-83), a U.S. Navy vessel in World War II