Manc or MANC may refer to:
- A derogatory term used in football to refer to either Manchester United or Manchester City, normally by opposition fans.
- Something pertaining to the city of Manchester, in North West England
- The Manchester dialect, or Manc accent, spoken in Manchester and outlying areas
- The MidAmerica Nazarene University, sometimes abbreviated to MANC
- The Cameroonian National Action Movement, known by its French acronym MANC
- Mancunian (disambiguation)