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Manamisoa is a rural commune in the Central Highlands of Madagascar. It belongs to the district of Ambalavao, which is a part of Haute Matsiatra Region. The population of the commune was estimated to be approximately 4,000 in 2001 commune census.

Only primary schooling is available. The majority 96% of the population of the commune are farmers, while an additional 1% receives their livelihood from raising livestock. The most important crops are rice and grapes; also cassava is an important agricultural product. Industry and services provide employment for 1% and 2% of the population, respectively.