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The Collaborative International Dictionary
Malignance

Malignance \Ma*lig"nance\, Malignancy \Ma*lig"nan*cy\, n. [See Malignant.]

  1. The state or quality of being malignant; extreme malevolence; bitter enmity; malice; disposition toward evil; intense ill will; as, malignancy of heart.

  2. Unfavorableness; evil nature.

    The malignancy of my fate might perhaps distemner yours.
    --Shak.

  3. (Med.) Virulence; tendency to a fatal issue; as, the malignancy of an ulcer or of a fever.

  4. Hence: (Med.) A cancerous tumor that is spreading beyond the point of origin.

    Syn: malignant tumor, malignant neoplasm, metastatic tumor.

  5. The state of being a malignant.

WordNet
malignance
  1. n. (medicine) a malignant state; progressive and resistant to treatment and tending to cause death [syn: malignancy]

  2. quality of being disposed to evil; intense ill will [syn: malignity, malignancy] [ant: benignity, benignity]

Usage examples of "malignance".

Compared with the senseless brutality of Wirz, the reckless deviltry of Davis, or the stupid malignance of Barrett, at Florence, his administration was mildness and wisdom itself.

And Vardanes, whose malignance was neither mediocre nor trivial, had coveted Alypia for years.

To Templars-to any human being except the perverted goodlife, but to Templars in particular-berserkers were malignance personified in metal.

A plunging, careening crate, propelled by a sudden vicious lurch as the campari plunged headlong into an exceptional trough, caught her back and shoulder and pitched her to the floor, pushing her along before its massive weight as if it were imbued with an almost human inhumanuality of evil and malignance and determined to crush the life out of her against the forward bulkhead.

Most of his party had been disbanded, not by the power of the explosion, but by the sheer malignance that alien attack evinced.

Whatever the source, there it was, a hair of great length which had, in its situation, behaved with the malignance of an animate thing!