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Longman Dictionary of Contemporary English
mainline
I.adjective
EXAMPLES FROM OTHER ENTRIES
mainline Protestant churches
▪ a mainline news network
EXAMPLES FROM CORPUS
▪ Following the first three axioms helps to mobilize these and bring them to the aid of the mainline medical program.
▪ In the physical realm, the nutrition and the mainline medicine were part of it, but more was needed.
▪ The extreme mechanistic approach that mainline medicine developed worked well for the great communicable killer diseases.
▪ Unfortunately mainline medicine has been very slow in applying the lesson in other areas.
II.verb
EXAMPLES FROM CORPUS
▪ I miss her intellect, her passion, her courage and her penchant for mainlining our nerves.
The Collaborative International Dictionary
mainline

mainline \main"line`\ (m[=a]n"l[imac]n`) v. t. 1. to inject (illegal drugs) into the vein; as, he preferred to mainline heroin rather than sniff coke.

Douglas Harper's Etymology Dictionary
mainline

also main-line, 1934, from main line in American English slang sense "principal vein into which drugs can be injected" (1933).

Wiktionary
mainline
  1. 1 normal, principal or standard. 2 (context rail transport English) Of or pertaining to the principal route or line of a railway. 3 (context rail transport English) Of or pertaining to a surface railway as distinct from an underground, elevated or light rail one. n. 1 (cx aviation English) An airline's main operating unit, as opposed to codeshares or regional subsidiaries. 2 (cx computing English) The main repository for a software project, from which different versions (forks) may be split off. v

  2. To inject (a drug) directly into a vein.

WordNet
mainline

v. inject into the vein; "She is mainlining heroin"

Wikipedia
Mainline

Mainline, Main line, or Main Line may refer to:

Mainline (aeronautics)

A mainline flight is a flight operated by an airline's main operating unit, rather than by regional alliances, regional code-shares or regional subsidiaries.

In the United States, examples of mainline passenger airline flights include those operated by American Airlines, Delta Air Lines, United Airlines, and now defunct US Airways; but not flights operated by regional airlines Envoy Air, Executive Airlines, Piedmont Airlines, or PSA Airlines with regional jets or the services of regional airline marketing brands such as American Eagle, Delta Connection, United Express, or US Airways Express aboard lower-capacity narrowbody jets and turboprop aircraft, such as those produced by Embraer or Bombardier, that do not have transcontinental range.

U.S. legacy carriers may operate branded mainline services using the same flight crews and AOC as that of their mainline operations. For example, United p.s. and American Flagship Service cater to the medium-haul transcontinental business segment. Short-haul air shuttles, such as Delta Shuttle, operate at high frequency intervals between busy city pairs. Previously, U.S. legacy carriers operated low-cost air services within their mainline operations to compete with low-cost carriers; these operations were short-lived and included brands such as Continental Lite, Song (Delta), and Ted (United).

An airline carrier's collective bargaining agreement with flight crews stipulates the maximum seating capacity of regional aircraft; as such, any aircraft that exceeds this capacity must operate as a mainline flight. The converse is not the case; mainline flight crews, with proper type ratings, may operate aircraft that are smaller than typical mainline aircraft.

Usage examples of "mainline".

Steward thought, marching in lockstep along the third level of the Vesta mainline centrifuge, Steward at the ardis, cleaving apart the Brighter Suns citizens.

It would take that long for enough sap to run from tree through lateral line to mainline to sugarhouse, to warrant firing up the evaporator.

I know of no other case in which the mainline media have let the tabloids take the lead and then reported on their reporting.

Aidan's, of course) who thought that these two elaborated the services beyond what was defensible in terms of mainline Anglicanism and the spirit of the Thirty-Nine Articles.

It occurred to Ryan that the speed they were moving at, on a brakeless vehicle, could leave them vulnerable to any kind of sabotage of the mainline track.

We've bought several years of absolute time to continue our work, and time is pretty much back on its original mainline track.

At its peak it had two mainline railway stations, eight music halls, eight cinemas, an aquarium, a funfair, a menagerie, a revolving tower, a boating garden, a Summer Pavilion, a Winter Gardens, the largest swimming-pool in Britain, and two piers.

Another man was on his way to the mainline station in Darlington to give them a hand.

There Patel got out with his burden, walked along the platform and took the escalator up through the tubelike corridor that led to the overpass which avoided the mainline BR tracks: then down the other side again, and out across the open concrete plaza from which jutted several large slabs of ancient wall, not much more than fieldstones mortared together—a remnant of the old days when the City of London was all the London there was, and that tiny square mileage had a proper defensive wall of its own.

Along with all of its municipal buildings, it included a few big old mainline churches, several of which had gotten together and started up a food bank.

During haulback we lost the gear for an hour due to the mainline parting.

Three-hundred-Gen mainlines (such as Teg, his collaterals and siblings) had proved themselves dependable for millennia.

The economy went into overdrive, mainlining raw materials from the new worlds.

But the local addicts have been mainlining Brown so long they're suspicious of the other, and when the distributors do lay hold of the white stuff they have to step on it and tint it brown or it won't sell.

Not well exactly, not mainlining caffeine the way he was, but this was no time to equivocate or go into details.